HEMOPHILIA AND THE GENETICS OF HEREDITARY: A BIBLIOGRAPHIC REVIEW ON COAGULATION DISORDER

Abstract

ABSTRACT

Difficulty in blood clotting occurs due to inhibition of clotting factors. The factors that suffer from this inhibition are factors VIII and IX, responsible for two types of hemophilia, hemophilia A and hemophilia B. To determine the severity of the disease in patients, the levels of these factors found must be taken into account in the blood of each patient. Therefore, this investigation aims to highlight different studies aimed at characterizing hematological disorders, more specifically hemophilia, both A and B, and genetic alterations arising from mutated chromosomes, which tend to generate patterns of inheritance. Through searches carried out in PubMed and Scielo, using the appropriate descriptors and inserting the inclusion and exclusion criteria, 12 articles were found. Finally, the work carried out within the medical genetics area, especially the development of gene therapies, is increasingly advanced and updated, bringing hope to those who are affected with some types of genetic diseases such as hemophilia.

Keywords: Hemophilia. Genetics. Heredity.